[生物] 清大92學年度生導期末考題

1.若要了解人類染色體的變異,常會用到Karyotype,請說明檢視哪一類細胞,分離的方法
  及製備過程.

2.請解釋以下五個遺傳學名詞
  (1) Multiple alleles (2) Pleiotropy (3) Epistatis (4) Phenotype
  (5) Genotype

3.在胎兒未出生前,即可對他做遺傳缺陷的檢驗,通常用兩個方法,即 Aminocentesis
  及 Chorionic villus sampling,請詳細說明其原理及步驟.

4.雌性哺乳動物在胎兒發育期有個特殊現象,X-inactivation,請說明其過程及意義.

5.請敘述及繪圖說明 DNA replicaiton 的詳細過程,並說明參與分子的特色.

6.以下五種生物被稱為發育生物學的  Model organisms:
  Danio rerio, Caenorhabditis elegans, Drosophila melanogaster,
  Arabidopsis thaliana 及 Mus musculus,請分別寫出其中文名字及簡述其特點.

7.請以果蠅為例,說明 Maternal effect genes 及 Homeotic genes的特色.

8.請深入討論 "Natural selection maintains sexual reproduction"這句話的涵義.

9.You are planning to study a gene that codes for an immuno-regulatory
 protein in mouse. You know the amino acid sequence of the protein.
  Explain how you may
  (1)identify the gene expressed in a specific type of white blood cells
     (WBC),
  (2)identify the gene for the regulatory peptide,
  (3)produce multiple copies of the gene for stude, and
  (4)produce a quantity of regulatory protein for evaluation as a potential
    drug.

10.The following is a messenger RNA (mRNA) you have identified in E. coli
   responding to a stimulatory treatment.

   5'-UUUGGCAUGAAAUGGAUUAAAUGGAUUUAAUAG-3'
   (1)Put down the sequence of the gene (dsDNA) that codes for this RNA,
      and label
      (a)The 5' and 3' ends
      (b)The positive and negative strand
      (c)The sense and antisense strand
      (d)The "template" strand
   (2)What is the amino acid sequence?

11.Although the basic transcrtption and traslation processes in procaryotic
   and eucaryotic cells are similar, there are major differences,
especially in the regulatory aspects(蛋白質表現之調控有重大的差異).
   Please compare the similarities and differences of these two processes
   in procaryotes and eucaryotes.

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